Do write down settings on everything you have mentioned to log a start point.
You mentioned that there is no real problem with the 450, I always found with a Holley / Rover combo it is easy to make a problem. If the thing does not bog, and the gas mileage is good then maybe just a check over ?
You won't get jetting right without either a session on some rollers or by fitting an AFR gauge, sure you can do some runs and check plug colour, bit hit and miss.
I fitted the 10.5 PV on the advice of Real Steel, the supplier of the new Holley, the bog I had is typical of a 390 apparently and their way of getting over it, and I think with a 25 thou shooter and some fiddling with pump settings.
If you have a nice idle and no bogging, then its really down to if you have a continuous and seamless delivery of power through to WOT.
I used to run without a bonnet on and watch the secondary linkage come in, commonly they do not open until very late. As you no doubt know there is a spring kit available ( I assume you have vac secondaries )
The 4.6 has vac secondaries and the first run on the rollers they did not open until late, and even then did not open fully, the lightest spring cured that, and did it turn into a gas guzzler - No !
Enjoy your playtime